Analysis of the structure of bacteremia and sensitivity to antibiotics of microorganisms isolated in intensive care units in an emergency hospital in the period from 2003 to 2021: a retrospective observational study

INTRODUCTION: Creation of protocols for effective empiric antimicrobial therapy is impossible without the analysis current antibiotic susceptibility data. OBJECTIVE: Analysis changes in etiological significance leading pathogens bacteremia ICU (intensive care unit) period from 2003 to 2021, and their sensitivity antibiotics; study types carbapenemases most relevant — Klebsiella pneumoniae Acinetobacter baumannii. MATERIALS AND METHODS: The included all microorganisms isolated blood patients who were medical 12-bed emergency hospital Moscow 2021. Identification determination carried out with an automatic PHOENIX analyzer a standardized disco diffusion method. Detection was by PCR (polymerase chain reaction). RESULTS: In 17 034 samples examined, which 6372 isolated. During this period, proportion Gram-negative increased 21.0 52.8 %, mainly due K. 1.0 24.5 % A. baumannii 0 9.1 %. resistance these carbapenems significantly 2008 2021: 2.3 70.3 7.5 99.5 produced following carbapenemases: OXA-48 (73.8 %), KPC (6.2 NDM 1.5 + (15.4 (3.1 %). All strains OXA-40 type carbapenemase. carbapenemase producers resistant colistin tigecycline 14.6 44.8 ceftazidime/avibactam 4.2 CONCLUSIONS: level recent years among very significant problem ICU. Most are characterized as multi-drug resistant, about 10 categorized extremely-drug (XDR) or pan-drug resistant. belong category XDR.